Effect of Phytate (InsP6) and Other Inositol-Phosphates (InsP5, InsP4, InsP3, InsP2) on Crystallization of Calcium Oxalate, Brushite, and Hydroxyapatite

Pathological calcifications may consist of calcium oxalate (CaOx), hydroxyapatite (HAP), and brushite (BRU). The objective this study was to evaluate the effect phytate (inositol hexakisphosphate, InsP6), InsP6 hydrolysates, individual lower InsPs (InsP5, InsP4, InsP3, InsP2) on crystallization CaOx, HAP BRU in artificial urine. All seem inhibit salts biological fluids, although our vitro results showed that InsP5 were stronger inhibitors CaOx crystallization, InsP4 crystallization. For specific experimental conditions we examined, had very weak effects it is likely a different mechanism responsible for vivo. example, calciprotein particles have an important role formation cardiovascular examined partially reproduced vivo but not